Jefferson Lab is a good place to find educational science and math games. I discovered this resource a few years ago because one of my 9th grade students was hooked on playing "Who Wants to Win $1,000,000?". The games and puzzles that you'll find are focused on math and science although one word game is thrown in for good measure.
Applications for Education
The games from Jefferson Lab could provide good practice in applying science and math knowledge to problem solving. Jefferson Lab also has a great Teacher Resources page full of lesson plans for hands-on activities, study pages, and reference materials.